Wat (wie) is nutritional cirrhosis - definitie
![Low-magnification [[micrograph]] of PBC, [[H&E stain]]](https://commons.wikimedia.org/wiki/Special:FilePath/Primary biliary cirrhosis low mag.jpg?width=200 "Low-magnification [[micrograph]] of PBC, [[H&E stain]]")
![Intermediate-magnification micrograph of PBC showing bile duct inflammation and periductal [[granuloma]]s, liver biopsy, H&E stain](https://commons.wikimedia.org/wiki/Special:FilePath/Primary biliary cirrhosis intermed mag.jpg?width=200 "Intermediate-magnification micrograph of PBC showing bile duct inflammation and periductal [[granuloma]]s, liver biopsy, H&E stain")
![sp100]] antibodies (nuclear dots) and antimitochondrial antibodies](https://commons.wikimedia.org/wiki/Special:FilePath/ANA NUCLEAR DOT AND AMA.jpg?width=200 "sp100]] antibodies (nuclear dots) and antimitochondrial antibodies")
![Caudate lobe]] [[hypertrophy]] on ultrasound due to cirrhosis](https://commons.wikimedia.org/wiki/Special:FilePath/Caudate lobe hypertrophy 0001.jpg?width=200 "Caudate lobe]] [[hypertrophy]] on ultrasound due to cirrhosis")
![[[Micrograph]] showing cirrhosis, [[trichrome stain]]](https://commons.wikimedia.org/wiki/Special:FilePath/Cirrhosis high mag.jpg?width=200 "[[Micrograph]] showing cirrhosis, [[trichrome stain]]")
![[[Hepatitis C]] viral particles and the liver](https://commons.wikimedia.org/wiki/Special:FilePath/Hepatitis C.jpg?width=200 "[[Hepatitis C]] viral particles and the liver")
![Hepatofugal (non-forward) flow in [[portal vein]]](https://commons.wikimedia.org/wiki/Special:FilePath/Hepatofugal flow in portal vein.jpg?width=200 "Hepatofugal (non-forward) flow in [[portal vein]]")
![transverse]] view](https://commons.wikimedia.org/wiki/Special:FilePath/Liver cirrhosis.JPG?width=200 "transverse]] view")
.jpg?width=200 "pmc=6914302}}-\"This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license\"")
.jpg?width=200 "Histopathology of steatohepatitis with mild fibrosis in the form of fibrous expansion (Van Gieson's stain)")
.jpg?width=200 "Histopathology of steatohepatitis with moderate fibrosis, with thin fibrous bridges (Van Gieson's stain)")
.jpg?width=200 "Histopathology of steatohepatitis with established cirrhosis, with thick bands of fibrosis (Van Gieson's stain)")
![[[Trichrome stain]], showing cirrhosis as a nodular texture surrounded by fibrosis (wherein collagen is stained blue).](https://commons.wikimedia.org/wiki/Special:FilePath/Cirrhosis of the liver (trichrome stain) (5690946257).jpg?width=200 "[[Trichrome stain]], showing cirrhosis as a nodular texture surrounded by fibrosis (wherein collagen is stained blue).")
.jpg?width=200 "Pale macronodules of cirrhosis.")
Wikipedia
Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is an autoimmune disease of the liver. It results from a slow, progressive destruction of the small bile ducts of the liver, causing bile and other toxins to build up in the liver, a condition called cholestasis. Further slow damage to the liver tissue can lead to scarring, fibrosis, and eventually cirrhosis.
Common symptoms are tiredness, itching, and in more advanced cases, jaundice. In early cases, the only changes may be those seen in blood tests.
PBC is a relatively rare disease, affecting up to one in 3,000–4,000 people. It is much more common in women, with a sex ratio of at least 9:1 female to male.
The condition has been recognised since at least 1851, and was named "primary biliary cirrhosis" in 1949. Because cirrhosis is a feature only of advanced disease, a change of its name to "primary biliary cholangitis" was proposed by patient advocacy groups in 2014.
